実際には方法があります。もちろん、これを行うには権限が必要です...
SET @sql = CONCAT('SELECT ', (SELECT REPLACE(GROUP_CONCAT(COLUMN_NAME), '<columns_to_omit>,', '') FROM INFORMATION_SCHEMA.COLUMNS WHERE TABLE_NAME = '<table>' AND TABLE_SCHEMA = '<database>'), ' FROM <table>');
PREPARE stmt1 FROM @sql;
EXECUTE stmt1;
<table>, <database> and <columns_to_omit>
を置き換える