遅いのはサブクエリではありません。実際、外部クエリから返された行ごとにこれらのサブクエリを実行しています。代わりにこれらを結合に移動すると、パフォーマンスの向上が見られるはずです。
SELECT
jobs.jobs_id, clients.nome_fantasia, concat_ws(' ', user_profiles.first_name, user_profiles.last_name) as fullname,
jobs.titulo_vaga, jobs.qtd_vagas, company.name as nome_company, jobs_status.name as status_name, DATEDIFF(NOW(), jobs.data_abertura) as date_idade,
qtd.qtd_int,
fechadas.fechadas
FROM (jobs)
JOIN clients ON lients.clients_id=jobs.clients_idJOIN user_profiles ON jobs.consultor_id=user_profiles.user_id
JOIN jobs_status ON jobs.status=jobs_status.jobs_status_id
JOIN company ON jobs.company_id=company.company_id
JOIN (
SELECT jobs_id, count(jobs_id) AS qtd_int FROM job_cv GROUP BY jobs_id
) AS qtd ON qtd.jobs_id = jobs.jobs_id
JOIN (
SELECT job_cv.user_id, count(distinct job_cv.user_id) AS fechadas
FROM job_cv_history
JOIN job_cv
ON job_cv.job_cv_id = job_cv_history.job_cv_id
WHERE job_cv_history.status = '11'
GROUP BY job_cv.user_id
) AS fechadas ON job_cv.jobs_id = jobs.jobs_id
LIMIT 50